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Review Article| Volume 107, ISSUE 3, P435-447, May 2023

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Chronic Hepatitis B Virus: What an Internist Needs to Know

Serologic Diagnosis, Treatment Options, and Hepatitis B Virus Reactivation
Published:February 20, 2023DOI:https://doi.org/10.1016/j.mcna.2022.12.002

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      References

        • Polaris Observatory Collaborators
        Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study.
        Lancet Gastroenterol Hepatol. 2018; 3: 383-403
        • Lok A.S.F.
        • McMahon B.J.
        Chronic hepatitis B.
        Hepatology. 2007; 45: 507-539
        • Le M.H.
        • Yeo Y.H.
        • Cheung R.
        • et al.
        Chronic hepatitis B prevalence among foreign-born and U.S.-born adults in the United States, 1999-2016.
        Hepatology. 2020; 71: 431-443
        • Xu J.J.
        • Tien C.
        • Chang M.
        • et al.
        Demographic and serological characteristics of Asian Americans with hepatitis B infection diagnosed at community screenings.
        J Viral Hepat. 2013; 20: 575-581
        • Hu K.Q.
        • Pan C.Q.
        • Goodwin D.
        Barriers to screening for hepatitis B virus infection in Asian Americans.
        Dig Dis Sci. 2011; 56: 3163-3171
        • Hyun S.
        • Ko O.
        • Kim S.
        • et al.
        Sociocultural barriers to hepatitis B health literacy in an immigrant population: a focus group study in Korean Americans.
        BMC Public Health. 2021; 21: 404
        • Kallman J.B.
        • Arsalla A.
        • Park V.
        • et al.
        Screening for hepatitis B, C and non-alcoholic fatty liver disease: a survey of community-based physicians.
        Aliment Pharmacol Ther. 2009; 29: 1019-1024
        • Foster T.
        • Hon H.
        • Kanwal F.
        • et al.
        Screening high risk individuals for hepatitis B: physician knowledge, attitudes, and beliefs.
        Dig Dis Sci. 2011; 56: 3471-3487
        • Ku K.C.
        • Li J.
        • Ha N.B.
        • et al.
        Chronic hepatitis B management based on standard guidelines in community primary care and specialty clinics.
        Dig Dis Sci. 2013; 58: 3626-3633
        • Nguyen N.H.
        • Nguyen V.
        • Trinh H.N.
        • et al.
        Treatment eligibility of patients with chronic hepatitis B initially ineligible for therapy.
        Clin Gastroenterol Hepatol. 2013; 11: 565-571
        • Zhang S.
        • Ristau J.T.
        • Trinh H.N.
        • et al.
        Undertreatment of Asian chronic hepatitis B patients on the basis of standard guidelines: a community-based study.
        Dig Dis Sci. 2012; 57: 1373-1383
        • Kim L.H.
        • Nguyen V.G.
        • Trinh H.N.
        • et al.
        Low treatment rates in patients meeting guideline criteria in diverse practice settings.
        Dig Dis Sci. 2014; 59: 2091-2099
        • Terrault N.A.
        • Bzowej N.H.
        • Chang K.M.
        • et al.
        AASLD guidelines for treatment of chronic hepatitis B.
        Hepatology. 2016; 63: 261-283
        • European Association for the Study of the Liver
        EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection.
        J Hepatol. 2017; 67: 370-398
        • Sarin S.K.
        • Kumar M.
        • Lau G.K.
        • et al.
        Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update.
        Hepatol Int. 2016; 10: 1-98
        • Nguyen M.H.
        • Wong G.
        • Gane E.
        • et al.
        Hepatitis B virus: advances in prevention, diagnosis, and therapy.
        Clin Microbiol Rev. 2020; 33: 000466-19
        • Goodman Z.D.
        Grading and staging systems for inflammation and fibrosis in chronic liver diseases.
        J Hepatol. 2007; 47: 598-607
        • Amarapurkar D.
        • Amarapurkar A.
        Indications of liver biopsy in the era of noninvasive assessment of liver fibrosis.
        J Clin Exp Hepatol. 2015; 5: 314-319
        • Wong G.L.H.
        Update of liver fibrosis and steatosis with transient elastography (Fibroscan).
        Gastroenterol Rep (Oxf). 2013; 1: 19-26
        • Barr G.
        • Ferraioli G.
        • Palmeri M.
        • et al.
        Elastography assessment of liver fibrosis: society of radiologists in ultrasound consensus conference statement.
        Ultrasound Q. 2016; 32: 94-107
        • Lim J.K.
        • Flamm S.L.
        • Singh S.
        • et al.
        Clinical guidelines committee of the american gastroenterological association. american gastroenterological association institute guideline on the role of elastography in the evaluation of liver fibrosis.
        Gastroenterology. 2017; 152: 1536-1543
        • EASL-ALEH Clinical Practice Guidelines
        Non-invasive tests for evaluation of liver disease severity and prognosis.
        J Hepatol. 2015; 63: 237-264
        • Terrault N.A.
        • Lok A.S.F.
        • McMahon B.J.
        • et al.
        Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance.
        Hepatology. 2018; 67: 1560-1599
        • Krist A.H.
        • Davidson K.W.
        • Barry M.J.
        • et al.
        • US Preventive Services Task Force
        Screening for hepatitis B virus infection in adolescents and adults: US preventive services task force recommendation statement.
        JAMA. 2020; 324: 2415-2422
      1. Centers for Disease Control and Prevention. Federal register notice #CDC-2022-07050 for Hepatitis B screening and testing.
        (Available at:) (Accessed November 30, 2022)
        • Fung J.
        • Lai C.L.
        • Seto W.K.
        • et al.
        Nucleoside/nucleotide analogues in the treatment of chronic hepatitis B.
        J Antimicrob Chemother. 2011; 66: 2715-2725
        • Lok A.S.F.
        • McMahon B.J.
        • Brown Jr., R.S.
        • et al.
        Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis.
        Hepatology. 2016; 63: 284-306
        • Jang J.W.
        • Choi J.Y.
        • Kim Y.S.
        • et al.
        Long-term effect of antiviral therapy on disease course after decompensation in patients with hepatitis B virus-related cirrhosis.
        Hepatology. 2015; 61: 1809-1820
        • Chien R.N.
        • Yeh C.T.
        • Tsai S.L.
        • et al.
        Determinants for sustained HBeAg response to lamivudine therapy.
        Hepatology. 2003; 38: 1267-1273
        • Fattovich G.
        • Stroffolini T.
        • Zagni I.
        • et al.
        Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
        Gastroenterology. 2004; 127: S35-S50
        • Chen C.J.
        • Yang H.I.
        • Su J.
        • et al.
        Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
        JAMA. 2006; 295: 65-73
        • Lok A.
        Does antiviral therapy for hepatitis B and C prevent hepatocellular carcinoma?.
        J Gastroenterol Hepatol. 2011; 26: 221-227
        • Yu M.
        • Lin C.
        • Lin C.
        • et al.
        Influence of metabolic risk factors on risk of hepatocellular carcinoma and liver-related death in men with chronic hepatitis B: a large cohort study.
        Gastroenterology. 2017; 153: 1006-1017.e5
        • Chan A.
        • Wong G.
        • Chan H.
        • et al.
        Concurrent fatty liver increases risk of hepatocellular carcinoma among patients with chronic hepatitis B.
        J Gastroenterol Hepatol. 2017; 32: 667-676
        • Huang Y.
        • Yang H.
        • Liu J.
        • et al.
        Mediation analysis of hepatitis B and C in relation to hepatocellular carcinoma risk.
        Epidemiology. 2016; 27: 14-20
        • Ioannou G.
        • Bryson C.
        • Weiss N.
        • et al.
        The prevalence of cirrhosis and hepatocellular carcinoma in patients with human immunodeficiency virus infection.
        Hepatology. 2013; 57: 249-257
        • Reddy K.R.
        • Beavers K.L.
        • Hammond S.P.
        • et al.
        American gastroenterological association institute guideline on the prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy.
        Gastroenterology. 2015; 148: 215-219
        • Myint A.
        • Tong M.J.
        • Beaven S.W.
        Reactivation of hepatitis B virus: a review of clinical guidelines.
        Clin Liver Dis. 2020; 15: 162-167
        • Su J.
        • Lim J.K.
        Hepatitis B virus reactivation in the setting of immunosuppressive drug therapy.
        Gastroenterol Hepatol. 2019; 15: 585-592
        • Lau G.K.K.
        • Yiu H.H.Y.
        • Fong D.Y.T.
        • et al.
        Early is superior to deferred preemptive lamivudine therapy for hepatitis B patients undergoing chemotherapy.
        Gastroenterology. 2003; 125: 1742-1749
        • Huang Y.H.
        • Hsiao L.T.
        • Hong Y.C.
        • et al.
        Randomized controlled trial of entecavir prophylaxis for rituximab-associated hepatitis B virus reactivation in patients with lymphoma and resolved hepatitis B.
        J Clin Oncol. 2013; 31: 2765-2772
        • Papatheodoridis G.V.
        • Lekakis V.
        • Voulgaris T.
        • et al.
        Hepatitis B virus reactivation associated with new classes of immunosuppressants and immunomodulators: a systematic review, meta-analysis, and expert opinion.
        J Hepatol. 2022; 77: 1670-1689
        • Hwang J.P.
        • Feld J.J.
        • Hammond S.P.
        • et al.
        Hepatitis B virus screening and management for patients with cancer prior to therapy: ASCO provisional clinical opinion update.
        J Clin Oncol. 2020; 38: 3698-3715
        • Kwak Y.E.
        • Stein S.M.
        • Lim J.K.
        Practice patterns in hepatitis B virus screening before cancer chemotherapy in a major US hospital network.
        Dig Dis Sci. 2018; 63: 61-71