Female Sexual Dysfunction

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      References

        • Wright J.J.
        • O'Connor K.M.
        Female sexual dysfunction.
        Med Clin North Am. 2015; 99: 607-628
        • Sungur M.Z.
        • Gunduz A.
        A comparison of DSM-IV-TR and DSM-5 definitions for sexual dysfunctions: critiques and challenges.
        J Sex Med. 2014; 11: 364-373
        • Masters W.
        • Johnson V.
        Human sexual response.
        Little, Brown and Company, Boston1966
        • Sand M.
        • Fisher W.A.
        Women’s endorsement of models of female sexual response: the nurses’ sexuality study.
        J Sex Med. 2007; 4: 708-719
        • Giles K.R.
        • McCabe M.P.
        Conceptualizing women’s sexual function: linear vs. circular models of sexual response.
        J Sex Med. 2009; 6: 2761-2771
        • Giraldi A.
        • Kristensen E.
        • Sand M.
        Endorsement of models describing response of men and women with a sexual partner: an online survey in a population sample of Danish adults ages 20-65 years.
        J Sex Med. 2015; 12: 116-128
        • Sarin S.
        • Amsel R.M.
        • Binik Y.M.
        Disentangling desire and arousal: a classificatory conundrum.
        Arch Sex Behav. 2013; 42: 1079-1100
        • DeRogatis L.R.
        • Clayton A.H.
        • Rosen R.C.
        • et al.
        Should sexual desire and arousal disorders in women be merged?.
        Arch Sex Behav. 2011; 40: 217-219
        • Segraves R.T.
        • Balon R.
        • Clayton A.
        Proposal for changes in diagnostic criteria for sexual dysfunctions.
        J Sex Med. 2007; 4: 567-580
        • American Psychiatric Association
        Diagnostic and statistical manual of mental disorders: DSM- IV-TR.
        American Psychiatric Publishing, Washington, DC2000
        • American Psychiatric Association
        Diagnostic and statistical manual of mental disorders.
        5th edition. American Psychiatric Publishing, Arlington (VA)2013
        • First M.B.
        • Reed G.M.
        • Hyman S.E.
        • et al.
        The development of the ICD-11 clinical descriptions and diagnostic guidelines for mental and behavioural disorders.
        World Psychiatry. 2015; 14: 82-90
        • Reed G.M.
        • Drescher J.
        • Krueger R.B.
        • et al.
        Disorders related to sexuality and gender identity in the ICD-11: revising the ICD-10 classification based on current scientific evidence, best clinical practices, and human rights considerations.
        World Psychiatry. 2016; 15: 205-221
        • Perelman M.A.
        The sexual tipping point: a mind/body model for sexual medicine.
        J Sex Med. 2009; 6: 629-632
        • Basson R.
        Female sexual response: the role of drugs in the management of sexual dysfunction.
        Obstet Gynecol. 2001; 98: 350-353
        • Hayes R.D.
        • Bennett C.M.
        • Fairley C.K.
        • et al.
        What can prevalence studies tell us about female sexual difficulty and dysfunction?.
        J Sex Med. 2006; 3: 589-595
        • Burri A.
        • Spector T.
        Recent and lifelong sexual dysfunction in female UK population sample: prevalence and risk factors.
        J Sex Med. 2001; 8: 2420-2430
        • Shifren J.L.
        • Monz B.U.
        • Russo P.A.
        • et al.
        Sexual problems and distress in United States women: prevalence and correlates.
        Obstet Gynecol. 2008; 112: 970-978
        • Kontula O.
        • Haavio-Mannila E.
        Sexual pleasures. Enhancement of sex life in Finland. 1971-1992.
        Aldershot Publishing, Dartmouth (NH)1995
        • Smith A.M.A.
        • Lyons A.
        • Ferris J.A.
        • et al.
        Incidence and persistence/recurrence of women’s sexual difficulties: findings from the Australian Longitudinal Study of Health and Relationships.
        J Sex Marital Ther. 2012; 38: 378-393
        • Fugl-Meyer K.S.
        Sexual disabilities and sexual problems.
        in: Fugl-Meyer K.S. Sex in Sweden. (pp 199). Swedish National Institute of Health, Stockholm (Sweden)2000
        • McCabe M.P.
        • Sharlip I.D.
        • Atalla E.
        • et al.
        Definitions of sexual dysfunctions in women and men: a consensus statement from the fourth International Consultation on Sexual Medicine 2015.
        J Sex Med. 2016; 13: 135-143
        • Khajehei M.
        • Doherty M.
        • Tilley M.
        An update on sexual function and dysfunction in women.
        Arch Womens Ment Health. 2015; 18: 423-433
        • Kingsberg S.A.
        • Clayton A.H.
        • Pfaus J.G.
        The female sexual response: current models, neurobiological underpinnings and agents currently approved or under investigation for the treatment of hypoactive sexual desire disorder.
        CNS Drugs. 2015; 29: 915-933
        • Schultz W.W.
        • van Andel P.
        • Sabeli I.
        • et al.
        Magnetic resonance imaging of male and female genitals during coitus and female sexual arousal.
        BMJ. 1999; 319: 1596-1600
        • Nastri C.O.
        • Lara L.A.
        • Ferriani R.A.
        • et al.
        Hormone therapy for sexual function in perimenopausal and postmenopausal women.
        Cochrane Database Syst Rev. 2013; (CD009672)
        • Shifren J.L.
        • Davis S.R.
        • Moreau M.
        • et al.
        Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study.
        Menopause. 2006; 13: 770
        • North American Menopause Society
        The role of testosterone therapy in postmenopausal women: position statement of the North American Menopause Society.
        Menopause. 2005; 12: 496
        • Davis S.R.
        • Worsley R.
        • Miller K.K.
        • et al.
        Androgens and female sexual function and dysfunction- findings from the fourth International Consultation of Sexual Medicine.
        J Sex Med. 2016; 13: 168-178
        • Fooladi E.
        • Davis S.R.
        An update on the pharmacological management of female sexual dysfunction.
        Expert Opin Pharmacother. 2012; 13: 2131-2142
        • Goldstat R.
        • Briganti E.
        • Tran J.
        • et al.
        Transdermal testosterone therapy improves well-being, mood, and sexual function in premenopausal women.
        Menopause. 2003; 10: 390-398
        • Cayan F.
        • Dilek U.
        • Pata O.
        • et al.
        Comparison of the effects of hormone therapy regimens, oral and vaginal estradiol, estradiol + drospirenone and tibolone, on sexual function in healthy postmenopausal women.
        J Sex Med. 2008; 5: 132-138
        • Wu M.H.
        • Pan H.A.
        • Wang S.T.
        • et al.
        Quality of life and sexuality changes in postmenopausal women receiving tibolone therapy.
        Climacteric. 2001; 4: 314
        • Nijland E.A.
        • Weijmar Schultz W.C.
        • Nathorst-Boös J.
        • et al.
        • LISA study investigators
        Tibolone and transdermal E2/NETA for the treatment of female sexual dysfunction in naturally menopausal women: results of a randomized active-controlled trial.
        J Sex Med. 2008; 5: 646-656
        • Constantine G.
        • Graham S.
        • Portman D.J.
        • et al.
        Female sexual function improved with ospemifene in postmenopausal women with vulvar and vaginal atrophy: results of a randomized, placebo-controlled trial.
        Climacteric. 2015; 18: 226-232
        • Portman D.J.
        • Bachman G.A.
        • Simon J.A.
        Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy.
        Menopause. 2013; 20: 623-630
        • Cui Y.
        • Zong H.
        • Yan H.
        • et al.
        Ospemifene, a novel selective estrogen receptor modulator for treating dyspareunia associated with postmenopausal vulvar and vaginal atrophy.
        J Sex Med. 2014; 11: 487-497
        • Vallejos X.
        • Wu C.
        Flibanserin: a novel, nonhormonal agent for the treatment of hypoactive sexual desire disorder in premenopausal women.
        J Pharm Pract. 2016; ([Epub ahead of print])
        • Simon J.A.
        • Kingsberg S.A.
        • Shumel B.
        • et al.
        Efficacy and safety of flibanserin in postmenopausal women with hypoactive sexual desire disorder: results of the SNOWDROP trial.
        Menopause. 2014; 21: 633-640
        • Gao Z.
        • Yang D.
        • Yu L.
        • et al.
        Efficacy and safety of flibanserin in women with hypoactive sexual desire disorder: a systematic review and meta-analysis.
        J Sex Med. 2015; 12: 2095-2104
        • Berman J.R.
        • Berman L.A.
        • Toler S.M.
        • et al.
        Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: a double-blind, placebo controlled study.
        J Urol. 2003; 170: 2333-2338
        • Basson R.
        • McInnes R.
        • Smith M.D.
        • et al.
        Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal disorder.
        J Womens Health Gend Based Med. 2002; 11: 367-377
        • Caruso S.
        • Intelisano G.
        • Lupo L.
        • et al.
        Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study.
        BJOG. 2001; 108: 623-628
        • Meston C.M.
        • Rellini A.H.
        • Telch M.J.
        Short- and long-term effects of Ginkgo biloba extract on sexual dysfunction in women.
        Arch Sex Behav. 2008; 37: 530-547
        • Ito T.Y.
        • Polan M.L.
        • Whipple B.
        • et al.
        The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status.
        J Sex Marital Ther. 2006; 32: 369-378
        • Wilson S.K.
        • Delk J.R.
        • Billups K.L.
        Treating symptoms of female sexual arousal disorder with the Eros-Clitoral Therapy Device.
        J Gend Specif Med. 2001; 4: 54-58
        • Seagraves R.T.
        • Clayton A.
        • Croft H.
        • et al.
        Bupropion sustained release for the treatment of hypoactive sexual desire disorder in premenopausal women.
        J Clin Psychopharmacol. 2004; 24: 339-342
        • Kinsberg S.A.
        • Tkachenko N.
        • Lucas J.
        • et al.
        Characterization of orgasmic difficulties by women: focus group evaluation.
        J Sex Med. 2013; 10: 2242-2250
        • Fisher C.
        • Cohen H.D.
        • Schiavi R.C.
        • et al.
        Patterns of female arousal during sleep and waking: vaginal thermoconductance studies.
        Arch Sex Behav. 1983; 12: 97-122
        • Wells B.L.
        Nocturnal orgasms: females’ perception of a “normal” sexual experience.
        J Sex Res. 1983; 22: 412-437
        • Komisaruk B.R.
        • Whipple B.
        Functional MRI of the brain during orgasm in women.
        Annu Rev Sex Res. 2005; 16: 62-86
        • Dunn K.M.
        • Cherkas L.F.
        • Spector T.D.
        Genetic influences on variation in female orgasmic function: a twin study.
        Biol Lett. 2005; 1: 260-263
        • Perlis R.H.
        • Laje G.
        • Smoller J.W.
        • et al.
        Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.
        Neuropsychopharmacology. 2009; 34: 1819-1828
        • Braun V.
        • Wilkinson S.
        Socio-cultural representations of the vagina.
        J Reprod Infant Psychol. 2001; 18: 17-32
        • Schick V.R.
        • Calabrese S.K.
        • Rima B.N.
        • et al.
        Genital appearance dissatisfaction: implications for women’s genital image self-consciousness, sexual esteem, sexual satisfaction, and sexual risk.
        Psychol Women Q. 2010; 34: 394-404
        • Birnbaum G.E.
        The meaning of heterosexual intercourse among women with female orgasmic disorder.
        Arch Sex Behav. 2003; 32: 61-71
        • Burri A.V.
        • Cherkas L.M.
        • Spector T.D.
        Emotional intelligence and its association with orgasmic frequency in women.
        J Sex Med. 2009; 6: 1930-1937
        • Rowland D.L.
        • Kolba T.N.
        Understanding orgasmic difficulty in women.
        J Sex Med. 2016; 13: 1246-1254
        • Laumann E.O.
        • Paik A.
        • Rosen R.C.
        Sexual dysfunction in the United States: prevalence and predictors.
        JAMA. 1999; 281: 537-544
        • Redelman M.
        A general look at female orgasm and anorgasmia.
        Sex Health. 2006; 3: 143-153
        • Meston C.M.
        • Hull E.
        • Levin R.J.
        • et al.
        Disorders of orgasm in women.
        in: Lue T.F. Basson R. Rosen R. Sexual dysfunctions in men and women. Health Publications, Paris2004 (Summary of Committee)
        • Kamenov Z.A.
        • Todorova M.K.
        • Christov V.G.
        Effect of tibolone on sexual function in late postmenopausal women.
        Folia Med (Plovdiv). 2007; 49: 41-48
        • Jacques J.D.
        • et al.
        Women’s sexual pain disorders.
        J Sex Med. 2010; 7: 616-631
        • Simonelli C.
        • EWluteri S.
        • Petrucelli F.
        • et al.
        Female sexual pain disorders: dyspareunia and vaginismus.
        Curr Opin Psychiatry. 2014; 27: 406-412
        • Cherner R.A.
        • Reissing E.D.
        A psychophysiological investigation of sexual arousal in women with lifelong vaginismus.
        J Sex Med. 2013; 42: 1605-1614
        • Goldstein A.T.
        • Pukall C.F.
        • Brown C.
        • et al.
        Vulvodynia: assessment and treatment.
        J Sex Med. 2016; 13: 572-590
        • Melzack R.
        The McGill Pain Questionnaire: major properties and scoring methods.
        Pain. 1975; 1: 277-299
        • Sullivan M.J.L.
        • Biship S.
        • Pivik J.
        The pain catastrophizing scale: development and validation.
        Psychol Assess. 1995; 7: 524-532
        • Desrochers G.
        • Bergeron S.
        • Khalife S.
        • et al.
        Fear avoidance and self-efficacy in relation to measure perceived self-efficacy in people with arthritis.
        Semin Arthritis Rheum. 1989; 32: 37-44
        • Hummel-Berry K.
        • Wallave K.
        • Herman H.
        Reliability and validity of the vulvar functional status questionnaire (VQ).
        J Womens Health Phys Therap. 2007; 31: 1605-1614
        • Friederich E.G.
        Vulvar vestibulitis syndrome.
        J Reprod Med. 1987; 32: 110
        • Foster D.
        • Kotox M.
        • Huang L.
        • et al.
        The tampon test for vulvodynia treatment outcomes research reliability construct validity, and responsiveness.
        Obstet Gynecol. 2009; 113: 825-832
        • Committee Opinion No. 659. American College of Obstetricians and Gynecologists
        The use of vaginal estrogen in women with a history of estrogen-dependent breast cancer.
        Obstet Gynecol. 2016; 127: e93-e96
        • Bachmann G.A.
        • Komi J.O.
        • Ospemifene Study Group
        Ospemifene effectively treats vulvovaginal atrophy in postmenopausal women: results from a pivotal phase 3 study.
        Menopause. 2010; 17: 480-486
        • Leo R.J.
        • Dewani S.
        A systematic review of the utility of antidepressant pharmacotherapy in the treatment of vulvodynia pain.
        J Sex Med. 2013; 10: 2497-2505
        • Rosen N.O.
        • Bergeron S.
        • Sadikaj G.
        • et al.
        Impact of male partner responses on sexual function in women with vulvodynia and their partners - a dyadic daily experience study.
        Health Psychol. 2014; 33: 823-831
        • Melles R.J.
        • Ter Kuile M.M.
        • Dewitte M.
        • et al.
        Automatic and deliberate affective associations with sexual stimuli in women with lifelong vaginismus before and after therapist aided exposure treatment.
        J Sex Med. 2014; 11: 786-799
        • Ter Kuile M.M.
        • Melles R.J.
        • Tuijnman-Raasveld C.C.
        • et al.
        Therapist aided exposure for women with lifelong vaginismus: mediators of treatment outcome: a randomized waiting list control trial.
        J Sex Med. 2015; 12: 1807-1819
        • Melnik T.
        • Hawton K.
        • McGuire H.
        Interventions for vaginismus.
        Cochrane Database Syst Rev. 2012; (CD001760)
        • Atlantis E.
        • Sullivan T.
        Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis.
        J Sex Med. 2012; 9: 1497-1507
        • Serretti A.
        • Chiesa A.
        Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis.
        J Clin Psychopharmacol. 2009; 29: 259-266
        • Clayton A.H.
        • Alkis A.R.
        • Parik N.H.
        • et al.
        Sexual dysfunction due to psychotropic medications.
        Psychiatr Clin North Am. 2016; 39: 427-463
        • Clayton A.H.
        • Montejo A.L.
        Major depressive disorder, antidepressants, and sexual dysfunction.
        J Clin Psychiatry. 2006; 67: 33-37
        • Taylor M.J.
        • Rudkin L.
        • Bullemor-Day P.
        • et al.
        Strategies for managing sexual dysfunction induced by antidepressant medication.
        Cochrane Database Syst Rev. 2013; (CD003382)
        • Landen M.
        • Eriksson E.
        • Agren H.
        • et al.
        Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors.
        J Clin Psychopharmacol. 1999; 19: 268-271
        • Nunberg H.G.
        • Hensley P.L.
        • Heiman J.R.
        • et al.
        Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial.
        JAMA. 2008; 300: 395-404
        • Lorenz T.A.
        • Meston C.M.
        Exercise improves sexual function in women taking antidepressants: results from a randomized crossover trial.
        Depress Anxiety. 2014; 31: 188-195
        • Ozmenler N.K.
        • Karlidere T.
        • Bozkurt A.
        • et al.
        Mirtazapine augmentation in depressed patients with sexual dysfunction due to selective serotonin reuptake inhibitors.
        Hum Psychopharmacol. 2008; 23: 321-326
        • Clayton A.
        • Kornstein S.
        • Prakash A.
        • et al.
        Changes in sexual functioning associated with duloxetine, escitalopram, and placebo in the treatment of patients with major depressive disorder.
        J Sex Med. 2007; 4: 917-929
        • Clayton A.H.
        • Croft H.A.
        • Horrigan J.P.
        • et al.
        Bupropion extended release compared with escitalopram: effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies.
        J Clin Psychiatry. 2006; 67: 736-746
        • Thase M.E.
        • Clayton A.H.
        • Haight B.R.
        • et al.
        A double-blind comparison between bupropion XL and venlafaxine XR: sexual functioning, antidepressant efficacy, and tolerability.
        J Clin Psychopharmacology. 2006; 26: 482-488
        • Kennedy S.H.
        • Fulton K.A.
        • Bagby R.M.
        • et al.
        Sexual function during bupropion or paroxetine treatment of major depressive disorder.
        Can J Psychiatry. 2006; 51: 234-242
        • Clayton A.H.
        • Pradko J.F.
        • Croft H.A.
        • et al.
        Prevalence of sexual dysfunction among newer antidepressants.
        J Clin Psychiatry. 2002; 63: 357-366