Polycystic Ovarian Syndrome


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      1. Consensus on women's health aspects of polycystic ovary syndrome (PCOS).
        Hum Reprod. 2012; 27: 14-24https://doi.org/10.1093/humrep/der1396
        • Wood J.R.
        • Dumesic D.A.
        • Abbott D.H.
        • et al.
        Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis.
        J Clin Endocrinol Metab. 2007; 92: 705-713
        • Ferriman D.
        • Gallwey J.D.
        Clinical assessment of body hair growth in women.
        J Clin Endocrinol Metab. 1961; 21: 1440-1447
        • Conway G.S.
        • Dewailly D.
        • Diamanti-Kandarakis E.
        • et al.
        The polycystic ovary syndrome: an endocrinological perspective from the European Society of Endocrinology.
        Eur J Endocrinol. 2014; 171: 489-498
        • Dunaif A.
        • Segal K.R.
        • Futterweit W.
        • et al.
        Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome.
        Diabetes. 1989; 38: 1165-1174
        • DeUgarte C.M.
        • Bartolucci A.A.
        • Azziz R.
        Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment.
        Fertil Steril. 2005; 83: 1454-1460
        • Tamega Ade A.
        • Aranha A.M.
        • Guiotoku M.M.
        • et al.
        Association between skin tags and insulin resistance.
        An Bras Dermatol. 2010; 85 ([in Portuguese]): 25-31
        • Plascencia Gomez A.
        • Vega Memije M.E.
        • Torres Tamayo M.
        • et al.
        Skin disorders in overweight and obese patients and their relationship with insulin.
        Actas Dermosifiliogr. 2014; 105: 178-185https://doi.org/10.1016/j.ad.2013.09.1008
        • Apridonidze T.
        • Essah P.A.
        • Iuorno M.J.
        • et al.
        Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome.
        J Clin Endocrinol Metab. 2005; 90: 1929-1935
        • Dokras A.
        • Bochner M.
        • Hollinrake E.
        • et al.
        Screening women with polycystic ovary syndrome for metabolic syndrome.
        Obstet Gynecol. 2005; 106: 131-137
        • Legro R.S.
        • Kunselman A.R.
        • Dodson W.C.
        • et al.
        Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women.
        J Clin Endocrinol Metab. 1999; 84: 165-169
        • Ehrmann D.A.
        • Barnes R.B.
        • Rosenfield R.L.
        • et al.
        Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
        Diabetes Care. 1999; 22: 141-146
        • Ehrmann D.A.
        • Kasza K.
        • Azziz R.
        • et al.
        Effects of race and family history of type 2 diabetes on metabolic status of women with polycystic ovary syndrome.
        J Clin Endocrinol Metab. 2005; 90: 66-71
        • Kelly C.J.
        • Speirs A.
        • Gould G.W.
        • et al.
        Altered vascular function in young women with polycystic ovary syndrome.
        J Clin Endocrinol Metab. 2002; 87: 742-746
        • Talbott E.
        • Guzick D.
        • Clerici A.
        • et al.
        Coronary heart disease risk factors in women with polycystic ovary syndrome.
        Arterioscler Thromb Vasc Biol. 1995; 15: 821-826
        • Vgontzas A.N.
        • Legro R.S.
        • Bixler E.O.
        • et al.
        Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance.
        J Clin Endocrinol Metab. 2001; 86: 517-520
        • Tasali E.
        • Van Cauter E.
        • Ehrmann D.A.
        Relationships between sleep disordered breathing and glucose metabolism in polycystic ovary syndrome.
        J Clin Endocrinol Metab. 2006; 91: 36-42
        • Schwimmer J.B.
        • Khorram O.
        • Chiu V.
        • et al.
        Abnormal aminotransferase activity in women with polycystic ovary syndrome.
        Fertil Steril. 2005; 83: 494-497
        • Barry J.A.
        • Kuczmierczyk A.R.
        • Hardiman P.J.
        Anxiety and depression in polycystic ovary syndrome: a systematic review and meta-analysis.
        Hum Reprod. 2011; 26: 2442-2451https://doi.org/10.1093/humrep/der197
        • McCartney C.R.
        • Eagleson C.A.
        • Marshall J.C.
        Regulation of gonadotropin secretion: implications for polycystic ovary syndrome.
        Semin Reprod Med. 2002; 20: 317-326
        • Ehrmann D.A.
        Polycystic ovary syndrome.
        N Engl J Med. 2005; 352: 1223-1236
        • Tsilchorozidou T.
        • Overton C.
        • Conway G.S.
        The pathophysiology of polycystic ovary syndrome.
        Clin Endocrinol (Oxf). 2004; 60: 1-17
        • Diamanti-Kandarakis E.
        • Dunaif A.
        Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications.
        Endocr Rev. 2012; 33: 981-1030https://doi.org/10.1210/er.2011-1034
        • Sam S.
        • Legro R.S.
        • Essah P.A.
        • et al.
        Evidence for metabolic and reproductive phenotypes in mothers of women with polycystic ovary syndrome.
        Proc Natl Acad Sci U S A. 2006; 103: 7030-7035
        • Legro R.S.
        • Kunselman A.R.
        • Demers L.
        • et al.
        Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome.
        J Clin Endocrinol Metab. 2002; 87: 2134-2138
        • Sam S.
        • Sung Y.A.
        • Legro R.S.
        • et al.
        Evidence for pancreatic beta-cell dysfunction in brothers of women with polycystic ovary syndrome.
        Metabolism. 2008; 57: 84-89
        • Fauser B.C.
        • Tarlatzis B.C.
        • Rebar R.W.
        • et al.
        Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group.
        Fertil Steril. 2012; 97: 28-38.e25https://doi.org/10.1016/j.fertnstert.2011.1009.1024
        • Keevil B.G.
        How do we measure hyperandrogenemia in patients with PCOS?.
        J Clin Endocrinol Metab. 2014; 99: 777-779https://doi.org/10.1210/jc.2014-1307
        • O'Reilly M.W.
        • Taylor A.E.
        • Crabtree N.J.
        • et al.
        Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione.
        J Clin Endocrinol Metab. 2014; 99: 1027-1036https://doi.org/10.1210/jc.2013-3399
        • Eilertsen T.B.
        • Vanky E.
        • Carlsen S.M.
        Anti-Mullerian hormone in the diagnosis of polycystic ovary syndrome: can morphologic description be replaced?.
        Hum Reprod. 2012; 27: 2494-2502https://doi.org/10.1093/humrep/des213
        • Legro R.S.
        • Arslanian S.A.
        • Ehrmann D.A.
        • et al.
        Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.
        J Clin Endocrinol Metab. 2013; 98: 4565-4592https://doi.org/10.1210/jc.2013-2350
        • Johnstone E.B.
        • Rosen M.P.
        • Neril R.
        • et al.
        The polycystic ovary post-Rotterdam: a common, age-dependent finding in ovulatory women without metabolic significance.
        J Clin Endocrinol Metab. 2010; 95: 4965-4972https://doi.org/10.1210/jc.2010-0202
        • Dewailly D.
        • Lujan M.E.
        • Carmina E.
        • et al.
        Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society.
        Hum Reprod Update. 2014; 20: 334-352https://doi.org/10.1093/humupd/dmt061
        • Martin K.A.
        • Chang R.J.
        • Ehrmann D.A.
        • et al.
        Evaluation and treatment of hirsutism in premenopausal women: an endocrine society clinical practice guideline.
        J Clin Endocrinol Metab. 2008; 93: 1105-1120https://doi.org/10.1210/jc.2007-2437
        • Usadi R.S.
        • Legro R.S.
        Reproductive impact of polycystic ovary syndrome.
        Curr Opin Endocrinol Diabetes Obes. 2012; 19: 505-511https://doi.org/10.1097/MED.0b013e328359ff92
        • Legro R.S.
        • Barnhart H.X.
        • Schlaff W.D.
        • et al.
        Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.
        N Engl J Med. 2007; 356: 551-566
        • Morin-Papunen L.
        • Rantala A.S.
        • Unkila-Kallio L.
        • et al.
        Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial.
        J Clin Endocrinol Metab. 2012; 97: 1492-1500https://doi.org/10.1210/jc.2011-3061
        • Palomba S.
        • Falbo A.
        • Carrillo L.
        • et al.
        Metformin reduces risk of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during gonadotropin-stimulated in vitro fertilization cycles: a randomized, controlled trial.
        Fertil Steril. 2011; 96: 1384-1390.e4
        • Legro R.S.
        • Brzyski R.G.
        • Diamond M.P.
        • et al.
        The pregnancy in polycystic ovary syndrome II study: baseline characteristics and effects of obesity from a multicenter randomized clinical trial.
        Fertil Steril. 2014; 101: 258-269.e8https://doi.org/10.1016/j.fertnstert.2013.08.056
        • Perales-Puchalt A.
        • Legro R.S.
        Ovulation induction in women with polycystic ovary syndrome.
        Steroids. 2013; 78: 767-772https://doi.org/10.1016/j.steroids.2013.05.005
        • Knowler W.C.
        • Barrett-Connor E.
        • Fowler S.E.
        • et al.
        Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
        N Engl J Med. 2002; 346: 393-403
        • Bates G.W.
        • Legro R.S.
        Longterm management of polycystic ovarian syndrome (PCOS).
        Mol Cell Endocrinol. 2013; 373: 91-97https://doi.org/10.1016/j.mce.2012.1010.1029
        • Escobar-Morreale H.F.
        • Botella-Carretero J.I.
        • Alvarez-Blasco F.
        • et al.
        The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery.
        J Clin Endocrinol Metab. 2005; 90: 6364-6369
        • Eid G.M.
        • Cottam D.R.
        • Velcu L.M.
        • et al.
        Effective treatment of polycystic ovarian syndrome with Roux-en-Y gastric bypass.
        Surg Obes Relat Dis. 2005; 1: 77-80
        • Harrison C.L.
        • Lombard C.B.
        • Moran L.J.
        • et al.
        Exercise therapy in polycystic ovary syndrome: a systematic review.
        Hum Reprod Update. 2011; 17: 171-183
        • Winters S.J.
        • Talbott E.
        • Guzick D.S.
        • et al.
        Serum testosterone levels decrease in middle age in women with the polycystic ovary syndrome.
        Fertil Steril. 2000; 73: 724-729
        • Welt C.K.
        • Carmina E.
        Clinical review: lifecycle of polycystic ovary syndrome (PCOS): from in utero to menopause.
        J Clin Endocrinol Metab. 2013; 98: 4629-4638