Update on Diabetes Classification

  • Celeste C. Thomas
    Correspondence
    Corresponding author. Department of Medicine, The University of Chicago, 900 East 57th Street, Chicago, IL 60637.
    Affiliations
    Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA
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  • Louis H. Philipson
    Affiliations
    Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 5841 South Maryland Avenue, MC 1027, Chicago, IL 60637, USA

    Department of Pediatrics, Section of Endocrinology, Diabetes and Metabolism, The University of Chicago, 900 East 57th Street, Chicago, IL 60637, USA
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      References

      1. World Health Organization: World Health Organization, International Diabetes Federation, editors. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Report of a WHO/IDF Consultation. Geneva (Switzerland): WHO Press; 2006.

        • American Diabetes Association
        Diagnosis and classification of diabetes mellitus.
        Diabetes Care. 2014; 37: S81-S90
      2. World Health Organization. Use of glycated haemoglobin (HbA1c) in diagnosis of diabetes mellitus: abbreviated report of a WHO consultation. WHO Press; 2011.

        • American Diabetes Association
        Standards of medical care in diabetes–2013.
        Diabetes Care. 2012; 36: S11-S66https://doi.org/10.2337/dc13-S011
        • Atkinson M.A.
        • Eisenbarth G.S.
        • Michels A.W.
        Type 1 diabetes.
        Lancet. 2013; 383: 69-82
        • Naik R.G.
        • Brooks-Worrell B.M.
        • Palmer J.P.
        Latent autoimmune diabetes in adults.
        J Clin Endocrinol Metab. 2009; 94: 4635-4644https://doi.org/10.1210/jc.2009-1120
        • Arvan P.
        • Pietropaolo M.
        • Ostrov D.
        • et al.
        Islet autoantigens: structure, function, localization, and regulation.
        Cold Spring Harb Perspect Med. 2012; 2 (pii:a007658)
        • Bottazzo G.F.
        • Florin-Christensen A.
        • Doniach D.
        Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies.
        Lancet. 1974; 2: 1279-1283
        • Rose N.R.
        • Bona C.
        Defining criteria for autoimmune diseases (Witebsky's postulates revisited).
        Immunol Today. 1993; 14: 426-430https://doi.org/10.1016/0167-5699(93)90244-F
        • Atkinson M.A.
        • Bluestone J.A.
        • Eisenbarth G.S.
        • et al.
        How does type 1 diabetes develop? The notion of homicide or β-cell suicide revisited.
        Diabetes. 2012; 60: 1370-1379
      3. Maganti A, Evans-Molina C, Mirmira RG. From immunobiology to β-cell biology: the changing perspective on type 1 diabetes. Islets 2014;6(1):e28778-1–5. http://dx.doi.org/10.4161/isl.28778.

        • Noble J.A.
        • Johnson J.
        • Lane J.A.
        • et al.
        HLA Class II genotyping of african american type 1 diabetic patients reveals associations unique to african haplotypes.
        Diabetes. 2013; 62: 3292-3299
        • Valdes A.M.
        • Erlich H.A.
        • Carlson J.
        • et al.
        Use of class I and class II HLA loci for predicting age at onset of type 1 diabetes in multiple populations.
        Diabetologia. 2012; 55: 2394-2401https://doi.org/10.1007/s00125-012-2608-z
        • Redondo M.J.
        • Fain P.R.
        • Krischer J.P.
        • et al.
        Expression of beta-cell autoimmunity does not differ between potential dizygotic twins and siblings of patients with type 1 diabetes.
        J Autoimmun. 2004; 23: 275-279https://doi.org/10.1016/j.jaut.2004.07.001
        • Melanitou E.
        • Fain P.
        • Eisenbarth G.S.
        Genetics of type 1A (immune mediated) diabetes.
        J Autoimmun. 2003; https://doi.org/10.1016/S0896-8411(03)00097-0
        • Kyvik K.O.
        Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins.
        BMJ. 1995; 311: 913-917
      4. UK prospective diabetes study 16: overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group.
        Diabetes. 1995; 44: 1249-1258
        • Karjalainen J.
        • Salmela P.
        • Ilonen J.
        A comparison of childhood and adult type I diabetes mellitus.
        N Engl J Med. 1989; 320: 881-886
        • Fourlanos S.
        • Dotta F.
        • Greenbaum C.J.
        • et al.
        Latent autoimmune diabetes in adults (LADA) should be less latent.
        Diabetologia. 2005; https://doi.org/10.1007/s00125-005-1960-7
        • Gottsäter A.
        • Landin-Olsson M.
        • Fernlund P.
        • et al.
        β-cell function in relation to islet cell antibodies during the first 3 Yr after clinical diagnosis of diabetes in type ii diabetic patients.
        Diabetes Care. 1993; 16: 902-910https://doi.org/10.2337/diacare.16.6.902
        • Turner R.
        • Stratton I.
        • Horton V.
        • et al.
        UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes.
        Lancet. 1997; 350: 1288-1293https://doi.org/10.1016/S0140-6736(97)03062-6
        • Tuomi T.
        • Carlsson A.
        • Li H.
        • et al.
        Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies.
        Diabetes. 1999; 48: 150-157https://doi.org/10.2337/diabetes.48.1.150
        • Gale E.
        Is type 2 diabetes a category error?.
        Lancet. 2013; 381: 1956-1957
        • Mohan V.
        • Amutha A.
        • Ranjani H.
        • et al.
        Associations of β-cell function and insulin resistance with youth-onset type 2 diabetes and prediabetes among Asian Indians.
        Diabetes Technol Ther. 2013; 15: 315-322https://doi.org/10.1089/dia.2012.0259
        • Mitsui R.
        • Fukushima M.
        • Nishi Y.
        • et al.
        Factors responsible for deteriorating glucose tolerance in newly diagnosed type 2 diabetes in Japanese men.
        Metabolism. 2006; 55: 53-58https://doi.org/10.1016/j.metabol.2005.07.006
        • Butler A.E.
        • Janson J.
        • Bonner-Weir S.
        • et al.
        β-cell deficit and increased β-Cell apoptosis in humans with type 2 diabetes.
        Diabetes. 2003; 52: 102-110https://doi.org/10.2337/diabetes.52.1.102
        • Bell G.I.
        • Polonsky K.S.
        Diabetes mellitus and genetically programmed defects in β-cell function.
        Nature. 2001; 414: 788-791https://doi.org/10.1038/414788a
        • Del Prato S.
        Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies.
        Diabet Med. 2009; 26: 1185-1192
        • Epstein F.H.
        • Höppener J.
        • Ahrén B.
        Islet amyloid and type 2 diabetes mellitus.
        N Engl J Med. 2000; https://doi.org/10.1056/NEJM200008103430607
        • Meigs J.B.
        • Muller D.C.
        • Nathan D.M.
        • et al.
        The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging.
        Diabetes. 2003; 52: 1475-1484
        • Winter W.E.
        • Maclaren N.K.
        • Riley W.J.
        Maturity-onset diabetes of youth in black Americans.
        N Engl J Med. 1987; 316: 285-291
        • Mauvais-Jarvis F.
        • Sobngwi E.
        • Porcher R.
        • et al.
        Ketosis-prone type 2 diabetes in patients of Sub-Saharan African origin clinical pathophysiology and natural history of β-cell dysfunction and insulin resistance.
        Diabetes. 2004; 53: 645-653https://doi.org/10.2337/diabetes.53.3.645
        • Umpierrez G.E.
        • Smiley D.
        • Kitabchi A.E.
        Narrative review: ketosis-prone type 2 diabetes mellitus.
        Ann Intern Med. 2006; 144: 350-357https://doi.org/10.7326/0003-4819-144-5-200603070-00011
        • Tanaka K.
        • Moriya T.
        • Kanamori A.
        • et al.
        Analysis and a long-term follow up of ketosis-onset Japanese NIDDM patients.
        Diabetes Res Clin Pract. 1999; 44: 137-146https://doi.org/10.1016/S0168-8227(99)00023-6
        • Tan K.C.
        • Mackay I.R.
        • Zimmet P.Z.
        • et al.
        Metabolic and immunologic features of Chinese patients with atypical diabetes mellitus.
        Diabetes Care. 2000; https://doi.org/10.2337/diacare.23.3.335
        • Lowe L.P.
        • Metzger B.E.
        • Dyer A.R.
        • et al.
        Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Associations of maternal A1C and glucose with pregnancy outcomes.
        Diabetes. 2012; 35: 574-580
        • International Association of Diabetes and Pregnancy Study Groups Consensus Panel
        • Metzger B.E.
        • Gabbe S.G.
        International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.
        Diabetes Care. 2010; 33: 676-682
        • Gynecologists ACOOA
        • Committee on Practice Bulletins—Obstetrics
        ACOG Practice Bulletin No. 137. Gestational Diabetes Mellitus.
        Obstet Gynecol. 2013; 122: 406-416
        • Pihoker C.
        • Gilliam L.K.
        • Ellard S.
        Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: results from the SEARCH for Diabetes in Youth.
        J Clin Endocrinol Metab. 2013; https://doi.org/10.1210/jc.2013-1279
        • Greeley S.
        • Naylor R.N.
        • Philipson L.H.
        • et al.
        Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment.
        Curr Diab Rep. 2011; https://doi.org/10.1007/s11892-011-0234-7
        • Shankar R.K.
        • Pihoker C.
        • Dolan L.M.
        • et al.
        Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study.
        Pediatr Diabetes. 2012; 14: 174-180https://doi.org/10.1111/pedi.12003
        • Fajans S.S.
        • Bell G.I.
        • Polonsky K.S.
        Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.
        N Engl J Med. 2001; https://doi.org/10.1056/nejmra002168
        • Naylor R.N.
        • Greeley S.
        • Bell G.I.
        Genetics and pathophysiology of neonatal diabetes mellitus.
        J Diabetes Investig. 2011; https://doi.org/10.1111/j.2040-1124.2011.00106.x
        • Shields B.M.
        • Hicks S.
        • Shepherd M.H.
        • et al.
        Maturity-onset diabetes of the young (MODY): how many cases are we missing?.
        Diabetologia. 2010; 53: 2504-2508https://doi.org/10.1007/s00125-010-1799-4
        • Lango Allen H.
        • Johansson S.
        • Ellard S.
        • et al.
        Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes.
        Diabetes. 2009; 59: 266-271https://doi.org/10.2337/db09-0555
        • Shepherd M.
        • Shields B.
        • Ellard S.
        • et al.
        A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulintreated patients.
        Diabet Med. 2009; 26: 437-441https://doi.org/10.1111/j.1464-5491.2009.02690.x
        • Steele A.M.
        • Shields B.M.
        • Wensley K.J.
        • et al.
        Prevalence of vascular complications among patients with glucokinase mutations and prolonged, mild hyperglycemia.
        JAMA. 2014; https://doi.org/10.1001/jama.2013.283980
        • Naylor R.N.
        • Philipson L.H.
        Who should have genetic testing for maturity-onset diabetes of the young?.
        Clin Endocrinol (Oxf). 2011; 75: 422-426
        • Maassen J.A.
        • Hart L.M.
        • van Essen E.
        • et al.
        Mitochondrial Diabetes Molecular Mechanisms and Clinical Presentation.
        Diabetes. 2004; 53: S103-S109https://doi.org/10.2337/diabetes.53.2007.S103
        • Maassen J.A.
        • 't Hart L.M.
        • Janssen G.M.
        • et al.
        Mitochondrial diabetes and its lessons for common Type 2 diabetes.
        Biochem Soc Trans. 2006; 34: 819https://doi.org/10.1042/BST0340819
        • Battezzati A.
        • Mari A.
        • Zazzeron L.
        • et al.
        Identification of insulin secretory defects and insulin resistance during oral glucose tolerance test in a cohort of cystic fibrosis patients.
        Eur J Endocrinol. 2011; 165: 69-76
        • Ode K.L.
        • Moran A.
        New insights into cystic fibrosis-related diabetes in children.
        Lancet Diabetes Endocrinol. 2013; 1: 52-58
        • Gupte A.R.
        • Forsmark C.E.
        Chronic pancreatitis.
        Curr Opin Gastroenterol. 2014; 30: 500-505https://doi.org/10.1097/MOG.0000000000000094
        • Papita R.
        • Nazir A.
        • Anbalagan V.P.
        • et al.
        Secular trends of fibrocalculous pancreatic diabetes and diabetes secondary to alcoholic chronic pancreatitis at a Tertiary Care Diabetes Centre in South India.
        JOP. 2012; 13: 205-209https://doi.org/10.6092/1590-8577/608
        • Khatib O.M.
        Guidelines for the prevention, management and care of diabetes mellitus.
        WHO Press, World Health Organization2006
        • Hatunic M.
        • Finucane F.M.
        • Brennan A.M.
        • et al.
        Effect of iron overload on glucose metabolism in patients with hereditary hemochromatosis.
        Metabolism. 2010; https://doi.org/10.1016/j.metabol.2009.08.006
        • McClain D.A.
        • Abraham D.
        • Rogers J.
        • et al.
        High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis.
        Diabetologia. 2006; https://doi.org/10.1007/s00125-006-0200-0
        • Gullo L.
        • Pezzilli R.
        Diabetes and the risk of pancreatic cancer.
        N Engl J Med. 1994; 331: 81-84
        • Pannala R.
        • Basu A.
        • Petersen G.M.
        • et al.
        New-onset diabetes: a potential clue to the early diagnosis of pancreatic cancer.
        Lancet Oncol. 2009; 10: 88-95https://doi.org/10.1016/S1470-2045(08)70337-1
        • Permert J.
        • Ihse I.
        • Jorfeldt L.
        • et al.
        Pancreatic cancer is associated with impaired glucose metabolism.
        Eur J Surg. 1993; 159: 101-107
        • Muniraj T.
        • Chari S.T.
        Diabetes and pancreatic cancer.
        Minerva Gastroenterologica e Dietologica. 2014; : 1-22
        • Bramis K.
        • Gordon-Weeks A.N.
        • Friend P.J.
        • et al.
        Systematic review of total pancreatectomy and islet autotransplantation for chronic pancreatitis.
        Br J Surg. 2012; 99: 761-766https://doi.org/10.1002/bjs.8713
        • Ferris H.A.
        • Kahn C.R.
        New mechanisms of glucocorticoid-induced insulin resistance: make no bones about it.
        J Clin Invest. 2012; 122: 3854-3857
        • Deng C.
        Effects of antipsychotic medications on appetite, weight, and insulin resistance.
        Endocrinol Metab Clin North Am. 2013; https://doi.org/10.1016/j.ecl.2013.05.006
        • Baker R.A.
        • Pikalov A.
        • Tran Q.V.
        • et al.
        Atypical antipsychotic drugs and diabetes mellitus in the US Food and Drug Administration Adverse Event database: a systematic Bayesian signal detection analysis.
        Psychopharmacol Bull. 2009; 42: 11-31
        • Yates C.J.
        • Fourlanos S.
        • Colman P.G.
        • et al.
        Screening for new-onset diabetes after kidney transplantation: limitations of fasting glucose and advantages of afternoon glucose and glycated hemoglobin.
        Transplantation. 2013; 96: 726-731
        • Khong M.J.
        • Chong C.P.
        Prevention and management of new-onset diabetes mellitus in kidney transplantation.
        Neth J Med. 2014; 72: 127-134
        • Teutonico A.
        • Schena P.F.
        • Di Paolo S.
        Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus.
        J Am Soc Nephrol. 2005; 16: 3128-3135https://doi.org/10.1681/ASN.2005050487
        • Koster J.C.
        • Remedi M.S.
        • Qiu H.
        • et al.
        HIV protease inhibitors acutely impair glucose-stimulated insulin release.
        Diabetes. 2003; 52: 1695-1700
        • De Wit S.
        • Sabin C.A.
        • Weber R.
        • et al.
        Incidence and risk factors for new-onset diabetes in HIV-infected patients the data collection on adverse events of anti-HIV drugs (D:A:D) Study.
        Diabetes Care. 2008; 31: 1224-1229https://doi.org/10.2337/dc07-2013
        • Nix L.M.
        • Tien P.C.
        Metabolic syndrome, diabetes, and cardiovascular risk in HIV.
        Curr HIV/AIDS Rep. 2014; https://doi.org/10.1007/s11904-014-0219-7
        • Corrao G.
        • Ibrahim B.
        • Nicotra F.
        • et al.
        Statins and the risk of diabetes: evidence from a large population-based cohort study.
        Diabetes. 2014; https://doi.org/10.2337/dc13-2215
        • Kalra S.
        • Kalra B.
        • Agrawal N.
        Understanding diabetes in patients with HIV/AIDS.
        Diabetol Metab Syndr. 2011; 3: 2
      5. Centers for Medicare and Medicaid (CMS), National Center for Health Statistics. ICD-10-CM Official Guidelines for Coding and Reporting - 2014. US Department of Health and Human Services 2014.

      6. World Health Organization. International statistical classification of diseases and related health problems. WHO Press; 2004.

      7. Centers for Medicare and Medicaid (CMS), National Center for Health Statistics. ICD-9-CM Official Guidelines for Coding and Reporting - 2011. US Department of Health and Human Services 2011.